LIST BY YEAR: 202320222021 | 2020 | 2019 | 2018 | 201720162015  |  2014  |  2013  |  2012  |  2011  |  2010  |  2009  |  2008  |  2007  |  2006  |  2005

**Authors in BOLD denote Klein Lab members


  1. Trentesaux C*, Yamada T*, Klein OD, Lim WA. Harnessing synthetic biology to engineer organoids and tissues. Cell Stem Cell. 2023 Jan 5;30(1):10-19. Click Here to View
  2. Castillo-Azofeifa D, Wald T, Reyes EA, Gallagher A, Schanin J, Vlachos S, Lamarche-Vane N, Bomidi C, Blutt S, Estes MK, Nystul T, Klein OD. A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling. Cell Stem Cell. 2023 Feb 2;30(2):188-206.e6. Click Here to View
  3. Childs CJ, Holloway EM, Sweet CW, Tsai YH, Wu A, Vallie A, Eiken MK, Capeling MM, Zwick RK, Palikuqi B, Trentesaux C, Wu JH, Pellón-Cardenas O, Zhang CJ, Glass I, Loebel C, Yu Q, Camp JG, Sexton JZ, Klein OD, Verzi MP, Spence JR. EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids. JCI Insight. 2023 Mar 22;8(6):e165566.
  4. Naqvi S, Kim S, Hoskens H, Matthews HS, Spritz RA, Klein OD, Hallgrímsson B, Swigut T, Claes P, Pritchard JK, Wysocka J. Precise modulation of transcription factor levels identifiesfeatures underlying doage sensitivity. Nat Genet. 2023 May;55(5):841-851.
  5. Christensen MM, Hallikas O, Das Roy R, Väänänen V, Stenberg OE, Häkkinen TJ, François JC, Asher RJ, Klein OD, Holzenberger M, Jernvall J. The developmental basis for scaling of mammalian tooth size. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2300374120.
  6. Liu Y, Reyes E, Castillo-Azofeifa D, Klein OD, Nystul T, Barber DL. Intracellular pH dynamics regulates intestinal stem cell lineage specification. Nat Commun. 2023 Jun 23;14(1):3745.
  7. Aboujaoude E, Light J, Brown JEH, Boscardin WJ, Hallgrímsson B, Klein OD. Privacy, bias and the clinical use of facial recognition technology: A survey of genetics professionals. Am J Med Genet C Semin Med Genet. 2023 Sep;193(3):e32035.
  8. Bannister JJ, Wilms M, Aponte JD, Katz DC, Klein OD, Bernier FP, Spritz RA, Hallgrímsson B, Forkert ND. Comparing 2D and 3D representations for face-based genetic syndrome diagnosis. Eur J Hum Genet. 2023 Sep;31(9):1010-1016.
  9. Klein OD. Reconnecting, Recommitting, and Renewing. J Dent Res. 2023 Sep;102(10):1078-1079.
  10. Meli AP, Russell GA, Swaminathan S, Weichselbaum L, MacMahon CA, Pernet E, Karo-Atar D, Rogers D, Rochette A, Fontes G, Mandl JN, Divangahi M, Klein OD, Gregorieff A, Stäger S, King IL. Bcl-6 expression by CD4+ T cells determines concomitant immunity and host resistance across distinct parasitic infections. Mucosal Immunol. 2023 Sep 19:S1933-0219(23)00066-1.
  11. Luo Y, Yamada M, N'Tumba-Byn T, Asif H, Gao M, Hu Y, Marangoni P, Liu Y, Evans T, Rafii S, Klein OD, Voss HU, Hadjantonakis AK, Elemento O, Martin LA, Seandel M. SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline. Biol Reprod. 2023 Oct 13;109(4):533-551.
  12. Reyes EA*, Castillo-Azofeifa D*, Rispal J*, Wald T, Zwick RK, Palikuqi B, Mujukian A, Rabizadeh S, Gupta AR, Gardner JM, Boffelli D, Gartner ZJ, Klein OD. Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis. J Clin Invest. 2023 Oct 16;133(20):e163591.
  13. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Accepted at Nature Cell Biology.


  1. Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG. Microbial signals, MyD88, and lymphotoxin drive TNF-dependent intestinal epithelial tissue damage. J Clin Invest. 2022 Mar 1;132(5):e154993. Click Here to View
  2. Ma R, Gong D, You H, Xu C, Lu Y, Bergers G, Werb Z, Klein OD, Petritsch CK, Lu P. LGL1 binds to Integrin β1 and inhibits downstreams signaling to promote epithelial branching in the mammary gland. Cell Rep. 2022 Feb 15;38(7):110375. Click Here to View
  3. Pincha N, Marangoni P, Haque A, Klein OD. Parallels in signaling between development and regeneration in ectodermal organs. Curr Top Dev Biol. 2022;149:373-419. Epub 2022 Mar 26. Click Here to View
  4. Yu T*, Cazares O*, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, Brooks AN, Klein OD. SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal. Dev Cell. 2022 Mar 14;57(5):624-637.e4. Click Here to View
  5. Lo M, Sharir A, Paul MD, Torosyan H, Agnew C, Li A, Neben C, Marangoni P, Xu L, Raleigh DR, Jura N, Klein OD. CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids. Nat Commun. 2022 May 3;13(1):2407. Click Here to View
  6. Bannister J, Wilms M, Aponte D, Katz D, Klein OD, Bernier FP, Spritz R, Hallgrimsson B, Forkert ND. A Deep Invertible 3D Facial Shape Model For Interpretable Genetic Syndrome Diagnosis. IEEE J Biomed Health Inform. 2022 Jul;26(7):3229-3239. Click Here to View
  7. Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, Williams T, Niswander L, Calof AL, Lander AD, Visel A, Jirik FR, Cheverud JM, Klein OD, Birnbaum RY, Merrill AE, Ackermann RR, Graf D, Hemberger M, Dean W, Forkert ND, Murray SA, Westerberg H, Marcucio RS, Hallgrímsson B. MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses. Sci Data. 2022 May 25;9(1):230. Click Here to View
  8. Matthews H, Vanneste M, Katsura K, Aponte D, Patton M, Hammond P, Baynam G, Spritz R, Klein OD, Hallgrimsson B, Peeters H, Claes P. Refining nosology by modelling variation among facial phenotypes: the RASopathies. J Med Genet. 2022 Jul 20:jmedgenet-2021-108366. Click Here to View
  9. Palikuqi B, Rispal J, Reyes EA, Vaka D, Boffelli D, Klein OD. Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury. Cell Stem Cell. 2022 Aug 4;29(8):1262-1272.e5. Click Here to View
  10. Altés G, Vaquero M, Cuesta S, Anerillas C, Macià A, Espinet C, Ribera J, Bellusci S, Klein OD, Yeramian A, Dolcet X, Egea J, Encinas M. A dominant negative mutation uncovers cooperative control of Wolffian duct development by Sprouty genes. Cell Mol Life Sci. 2022 Sep 13;79(10):514. Click Here to View
  11. Pentinmikko N, Lozano R, Scharaw S, Andersson S, Englund JI, Castillo-Azofeifa D, Gallagher A, Broberg M, Song KY, Sola Carvajal A, Speidel AT, Sundstrom M, Allbritton N, Stevens MM, Klein OD, Teixeira A, Katajisto P. Cellular shape reinforces niche to stem cell signaling in the small intestine. Sci Adv. 2022 Oct 14;8(41):eabm1847. Click Here to View
  12. Klein OD, Nishinakamura R. Editorial overview: How to generate and maintain organs-organoids, regeneration and beyond. Curr Opin Genet Dev. 2022 Dec;77:102003. Click Here to View
  13. Bannister JJ, Wilms M, Aponte JD, Katz DC, Klein OD, Bernier FPJ, Spritz RA, Hallgrímsson B, Forkert ND. Detecting 3D syndromic faces as outliers using unsupervised normalizing flow models. Artif Intell Med. 2022 Dec;134:102425. Click Here to View
  14. Stevens AJ, Harris AR, Gerdts J, Kim KH, Trentesaux C, Ramirez JT, McKeithan WL, Fattahi F, Klein OD, Fletcher DA, Lim WA. Programming multicellular assembly with synthetic cell adhesion molecules. Nature. 2022 Dec 12. Epub ahead of print. Click Here to View


  1. Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ. Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition. Dev Cell. 2021 Feb 8;56(3):356-365.e9. Click Here to View
  2. Tallapragada NP, Cambra HM, Wald T, Keough Jalbert S, Abraham DM, Klein OD, Klein AM. Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids. Cell Stem Cell. 2021 Apr 24:S1934-5909(21)00159-4. Click Here to View
  3. Matthews HS, Palmer RL, Baynam GS, Quarrell OW, Klein OD, Spritz RA, Hennekam RC, Walsh S, Shriver M, Weinberg SM, Hallgrimsson B, Hammond P, Penington AJ, Peeters H, Claes PD. Large-scale open-source three-dimensional growth curves for clinical facial assessment and objective description of facial dysmorphism. Sci Rep. 2021 Jun 9;11(1):12175. Click Here to View
  4. Kim R, Yu T, Li J, Prochazka J, Sharir A, Green JBA, Klein OD. Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development. Development. 2021 Jul 15;148(14). Click Here to View
  5. Cazares O, Haque AS, Klein OD. Salivary gland: A budding genius. Dev Cell. 2021 Aug 23;56(16):2271-2272.
  6. Tidyman WE, Goodwin AF, Maeda Y, Klein OD, Rauen KA. MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model. Dis Model Mech. 2022 Feb 1;15(2):dmm049166.
  7. Shieh JT, Penon-Portmann M, Wong KHY, Levy-Sakin M, Verghese M, Slavotinek A, Gallagher RC, Mendelsohn BA, Tenney J, Beleford D, Perry H, Chow SK, Sharo AG, Brenner SE, Qi Z, Yu J, Klein OD, Martin D, Kwok PY, Boffelli D. Application of full-genome analysis to diagnose rare monogenic disorders. NPJ Genom Med. 2021 Oct 12;6(1):88.


  1. Ko J, Pomerantz JH, Perry H, Shieh JT, Slavotinek AM, Oberoi S, Klein OD. Case report of Floating-Harbor syndrome with bilateral cleft lip. Cleft Palate Craniofac J. 2020 Jan;57(1):132-136. Click Here to View
  2. Yu T, Klein OD. Molecular and cellular mechanisms of tooth development, homeostasis and repair. Development. 2020 Jan 24;147(2). pii: dev184754. Click Here to View
  3. Trentesaux C, Striedinger K, Pomerantz JH, Klein OD. From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells. Curr Opin Cel Biol. Curr Opin Cell Biol. 2020 Apr;63:88-101. Review. Click Here to View
  4. Körber I, Klein OD, Morhart P, Faschingbauer F, Grange DK, Clarke A, Bodemer C, Maitz S, Huttner K, Kirby N, Durand C, Schneider H. Safety and immunogenicity of Fc-EDA, a recombinant ectodysplasin A1 replacement protein, in human subjects. Br J Clin Pharmacol. 2020 Apr 6. [Epub ahead of print]. Click Here to View
  5. Bahar Halpern K, Massalha H, Zwick RK, Moor AE, Castillo-Azofeifa D, Rozenberg M, Farack L, Egozi A, Miller DR, Averbukh I, Harnik Y, Weinberg-Corem N, de Sauvage FJ, Amit I, Klein OD, Shoshkes-Carmel M, Itzkovitz S. Lgr5+ telocytes are a signaling source at the intestinal villus tip. Nat Commun. 2020 Apr 22;11(1):1936. Click Here to View
  6. Wall E, Scoles J, Joo A, Klein OD, Quinonez C, Bush JO, Martin GR, Laird DJ. The UCSF Mouse Inventory Database Application, an open source web app for sharing mutant mice within a research community. G3 (Bethesda). 2020 May 4;10(5):1503-1510. Click Here to View
  7. McKinley KL, Castillo-Azofeifa D, Klein OD. Tools and concepts for interrogating and defining cellular identity. Cell Stem Cell. 2020 May 7;26(5):632-656. Click Here to View
  8. Hallgrímsson B, Aponte JD, Katz DC, Bannister JJ, Riccardi SL, Mahasuwan N, McInnes BL, Ferrara TM, Lipman DM, Neves AB, Spitzmacher JAJ, Larson JR, Bellus GA, Pham AM, Aboujaoude E, Benke TA, Chatfield KC, Davis SM, Elias ER, Enzenauer RW, French BM, Pickler LL, Shieh JTC, Slavotinek A, Harrop AR, Innes AM, McCandless SE, McCourt EA, Meeks NJL, Tartaglia NR, Tsai AC, Wyse JPH, Bernstein JA, Sanchez-Lara PA, Forkert ND, Bernier FP, Spritz RA, Klein OD. Automated syndrome diagnosis by three-dimensional facial imaging. Genet Med. 2020 Jun 1. [Epub ahead of print]. Click Here to View
  9. Bannister JJ, Crites SR, Aponte JD, Katz DC, Wilms M, Klein OD, Bernier FPJ, Spritz RA, Hallgrímsson B, Forkert ND. Fully Automatic Landmarking of Syndromic 3D Facial Surface Scans Using 2D Images. Sensors (Basel). 2020 Jun 3;20(11):3171. Click Here to View
  10. Hagerling C, Owyong M, Sitarama V, Wang CY, Lin C, van den Bijgaart RJE, Koopman CD, Brenot A, Nanjaraj A, Wärnberg F, Jirström K, Klein OD, Werb Z, Plaks V. LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target. BMC Cancer. 2020 Jun 10;20(1):542. Click Here to View
  11. Goodwin AF, Chen CP, Vo NT, Bush JO, Klein OD. YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate. J Dent Res. 2020 Jul 6. Epub ahead of print. Click Here to View
  12. Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein OD, Zhao H, Zhang F, Linhardt RJ, Wang X. FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. BMC Biol. 2020 Jul 14;18(1):87. Click Here to View
  13. Rajendra C, Wald T, Barber K, Spence JR, Fattahi F, Klein OD. Generation of Knockout Gene-Edited Human Intestinal Organoids. Methods Mol Biol. 2020;2171:215-230. Click here to view
  14. Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y. FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research. Development. 2020 Sep 21;147(18):dev191213. Click here to view
  15. Krivanek J, Soldatov RA, Kastriti ME, Chontorotzea T, Herdina AN, Petersen J, Szarowska B, Landova M, Matejova VK, Holla LI, Kuchler U, Zdrilic IV, Vijaykumar A, Balic A, Marangoni P, Klein OD, Neves VCM, Yianni V, Sharpe PT, Harkany T, Metscher BD, Bajénoff M, Mina M, Fried K, Kharchenko PV, Adameyko I. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nat Commun. 2020 Sep 23;11(1):4816. Click here to view
  16. Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Alzamora MDP, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein O, Tuveson D, Braun BS, Shannon K. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 Sep 29:140495. Click here to view
  17. Lu Y, Deng R, You H, Xu Y, Antos C, Sun J, Klein OD, Lu P. Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium. Cell Rep. 2020 Oct 13;33(2):108246. Click here to view
  18. Toda S, McKeithan WL, Hakkinen TJ, Lopez P, Klein OD, Lim WA. Engineering synthetic morphogen systems that can program multicellular patterning. Science. 2020 Oct 16;370(6514):327-331. Click here to view
  19. Sweat YY, Sweat M, Yu W, Sanz-Navarro M, Zhang L, Sun Z, Eliason S, Klein OD, Michon F, Chen Z, Amendt BA. Sox2 Controls Periderm and Rugae Development to Inhibit Oral Adhesions. J Dent Res. 2020 Nov;99(12):1397-1405. Click here to view


  1. Jones KB, Furukawa S, Marangoni P, Ma H, Pinkard H, D'Urso R, Zilionis R, Klein AM, Klein OD. Quantitative clonal analysis and single-cell transcriptomics reveal division kinetics, hierarchy, and fate of oral epithelial progenitor cells. Cell Stem Cell. 2019 Jan 3;24(1): 183-192.e8. Click Here to View
  2. Singer D, Thamm K, Zhuang H, Karbanova J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PRC, Gulsen T, Liu KJ, Ardu S, Wann AK, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD, Attanasio M, Carmeliet P, Huttner WB, Corbeil D, Hu B. Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J. 2019 Jan 15;38(2). Click Here to View
  3. Wang TC, Martin MG, Kuo CJ, Klein OD, Niland JC. Introduction to themed series on intestinal stem cells and the NIDDK intestinal stem cell consortium. Am J Physiol Gastrointest Liver Physiol. 2019 Feb 1;316(2): G247-50. Click Here to View
  4. Castillo-Azofeifa D, Fazio EN, Nattiv R, Good HJ, Wald T, Pest MA, de Sauvage FJ, Klein OD, Asfaha S. Atoh1+ secretory progenitors possess renewal capacity independent of Lrg5+ cells during colonic regeneration. EMBO J. 2019 Feb 15;38(4). Click Here to View
  5. Neben CL, Lo M, Jura N, Klein OD. Feedback regulation of RTK signaling in development. Dev Biol. 2019 Mar 1;447(1): 71-89. Click Here to View
  6. Zwick RK, Ohlstein B, Klein OD. Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila. Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3): G313-22. Click Here to View
  7. Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. The society for craniofacial genetics and developmental biology 41st annual meeting. Am J Med Genet A. 2019 May;179(5):864-869. Click Here to View
  8. El Shahawy M, Reibring CG, Hallberg K, Neben CL, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. Sonic Hedgehog signaling is required for Cyp26 expression during embryonic development. Int J Mol Sci. 2019 May 8;20(9). Click Here to View
  9. Marangoni P, Charles C, Ahn Y, Seidel K, Jheon A, Ganss B, Krumlauf R, Viriot L, Klein OD. Downregulation of FGF signaling by Spry4 overexpression leads to shape impairment, enamel irregularities, and delayed signaling center formation in the mouse molar. JBMR Plus. 2019 Jul 31;3(8):e10205. Click Here to View
  10. Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu JK, Kawaguchi K, Castillo-Azofeifa D, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM, Klein OD. A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nat Cell Biol. 2019 Sep;21(9):1102-1112. Click Here to View  [Nature Cell Biology Cover - Click Here to View]
  11. Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE. Heterogeneity within stratified epithelial stem cell populations maintains the oral mucosa in response to physiological stress. Cell Stem Cell. 2019 Dec 5;25(6):814-829.e6. Click Here to View


  1. Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD. Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10, and Wnt5a. Hum Mol Genet. 2018 Jan;27(1):107-119. Click Here to View
  2. San-Navarro M, Seidel K, Sun Z, Bertonnier-Brouty L, Amendt BA, Klein OD, Michon F. Plasticity within the niche ensures the maintenance of a Sox2+  stem cell population in the mouse incisor. Development. 2018 Jan;145(1). Click Here to View
  3. Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrusova Z, Schneider RA, Klein OD, Gartner ZJ. Engineered tissue folding by mechanical compaction of the mesenchyme. Dev Cell. 2018 Jan;44(2):165-178.e6. Click Here to View  [Developmental Cell Cover - Click Here to View]
  4. Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. Epithelial WNT ligands are essential drivers of intestinal stem cell activation. Cell Rep. 2018 Jan;22(4):1003-1015. Click Here to View
  5. Larson JR, Manyama MF, Cole JB, Gonzalez PN, Percival CJ, Liberton DK, Ferrara TM, Riccardi SL, Kimwaga EA, Mathayo J, Spitzmacher JA, Rolian C, Jamniczky HA, Weinberg SM, Roseman CC, Klein O, Lukowiak K, Spritz RA, Hallgrimsson B. Body size and allometric variation in facial shape in children. Am J Phys Anthropol. 2018 Feb;165(2):327-42. Click Here to View
  6. Giannobile WV, Chai Y, Chen Y, Healy KE, Klein O, Lane N, Longaker MT, Lotz JC, Mooney DJ, Sfeir CS, Urata M, Wagner WR, Wu BM, Kohn DH. Dental, oral and craniofacial regenerative medicine: transforming biotechnologies for innovating patient care. Journal of Dental Research. 2018 Apr;97(4): 361-63. Click Here to View
  7. Kalha S, Shrestha B, Sanz Navarro M, Jones KB, Klein OD, Michon F. Bmi1+ progenitor cell dynamics in murine cornea during homeostasis and wound healing. Stem Cells. 2018 Apr;36(4): 562-73. Click Here to View
  8. Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E. FGF signaling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun. 2018 Jun 13;9(1): 2333. Click Here to View
  9. McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Deiling M, Klein OD, Vale RD. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 Jun 13;7. Click Here to View
  10. Castillo-Azofeifa DSeidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA. SOX2 Regulation by hedgehog signaling controls adult lingual epithelium homeostasis. Development. 2018 July 17;145(14). Click Here to View
  11. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 Jul;559(7712): 109-13. Click Here to View   [Commentary on our paper in Cell Stem Cell - Click Here to View]
  12. Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Soylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D, Undiagnosed Diseases Network, Brigham and Women’s Hospital FaceBase Project, Brigham Genomic Medicine (BGM). An integrated clinical program and crowdsourcing strategy forgenomic sequencing and Mendelian disease gene discovery. NPJ Genom Med. 2018 Aug 13;3:21. Click Here to View
  13. Herrero D, Canon S, Pelacho B, Salvador-Bernaldez M, Aguilar S, Pogontke C, Carmona RM, Salvador Jm, Perez-Pomares, Klein OD, Prosper E, Jimenez-Borreguero LJ, Bernad A. Bmi-1 progenitor cell ablation impairs the angiogenic response to myocardial infarction. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2160-2173. doi: 10.1161/ATVBAHA.118.310778. Click Here to View
  14. Weichselbaum L, Klein OD. The intestinal epithelial response to damage. 2018 Oct; 61(10):1205-1211. Click Here to View
  15. Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore D, Ingraham HA. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 Oct;9(1):4055. Click Here to View
  16. Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, Lopez ML, Wei Y, Marshall CD, Shen EZ, Jones RE, Sharir A, Klein OD, Chan CKF, Wan DC, Chang HY, Longaker MT. Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. Nature. 2018 Oct 24. Click Here to View
  17. Calamari ZT, Hu JK, Klein OD. Tissue mechanical forces and evolutionary developmental changes act through space and time to shape tooth morphology and function. Bioessays. 2018 Nov 2:e1800140. Click Here to View
  18. May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein O, Knox SM. Diverse progenitor cells preserve salivary gland ductal architecture after radiation induced damage. Development. 2018 Nov 5;145(21). Click Here to View
  19. Prochazkova M, Prochazka J, Marangoni P, Klein OD. Bones, glands, ears and more: the multiple roles of FGF10 in craniofacial development. Front Genet. 2018 Nov 16;9:542. Click Here to View


  1. Cole JB, Manyama M, Larson JR, Liberton DK, Ferrara TM, Riccardi SL, Li M, Mio W, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA. Human facial shape and size heritability and genetic correlations. Genetics. 2017 Feb;205(2):967-78.  Click Here to View
  2. Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R. Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proc Natl Acad Sci U S A. 2017 Feb;114(9). Click Here to View
  3. Niethamer TK, Larson AR, O'Neil AK, Bershteyn M, Hsiao EC, Klein O, Pomerantz JH, Bush JO. EPHRIN-B1 mosaicism drives cell segregation in craniofrontonasal syndrome hiPCS-Derived neuroepithlial cells. Stem Cell Reports. 2017 Mar;8(3):529-37. Click Here to View
  4. Tsai YH, Nattiv R, Dedhia PH, Nagy MS, Chin AM, Thomson M, Klein OD, Spence J. In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development. 2017 Mar;144(6):1045-55. Click Here to View
  5. Seidel K, Marangoni P, Tang C, Houshmand B, Du W, Maas RL, Murray S, Oldham MC, Klein OD. Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis. Elife. 2017 May;6. pii: e24712. Click Here to View
  6. Percival CJ, Marangoni P, Tapaltsyan V, Klein O, Hallgrímsson B. The interaction of genetic background and mutational effects in regulation of mouse craniofacial shape. G3 (Bethesda). 2017 May;7(5):1439-50. Click Here to View
  7. Kim R, Green JBA, Klein OD. From snapshots to movies: Understanding early tooth development in four dimensions. Dev Dyn. 2017 Jun;246(6):442-50. Click Here to View
  8. Cao H, Alrejaye N, Klein OD, Goodwin AF, Oberoi S. A review of craniofacial and dental findings of the RASopathies. Orthod Craniofac Res. 2017 Jun;20 Suppl 1:32-8. Click Here to View
  9. Prochazkova M, Häkkinen TJ, Prochazka J, Spoutil F, Jheon AH, Ahn Y, Krumlauf R, Jernvall J, Klein OD. FGF signaling refines Wnt gradients to regulate the patterning of taste papillae. Development. 2017 Jun;144(12):2212-21. Click Here to View
  10. El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017 Jul;13(7):e1006914. Click Here to View
  11. Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein OD. An FAK-YAP-mTOR signaling axis regulates stem cell-based tissue renewal in mice. Cell Stem Cell. 2017 Jul;21(1):91-106.e6. Click Here to View   [Commentary on our paper in BioEssays - Click Here to View]
  12. Du W, Hu JK, Du W, Klein OD. Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers. J Biol Chem. 2017 Sep;292(36):15062-9. Click Here to View
  13. Hadj-Rabia S, Schneider H, Navarro E, Klein O, Kirby N, Huttner K, Wolf L, Orin M, Wohlfart S, Bodemer C, Grange DK. Automatic recognition of the XLHED phenotype from facial images. Am J Med Genet A. 2017 Sep;173(9):2408-414. Click Here to View
  14. Kousa YA, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, Klein OD, Schutte BC. IRF6 and SPRY4 signaling interact in periderm development. J Dent Res. 2017 Oct;96(11): 1306-13. Click Here to View
  15. Zheng X, Goodwin AF, Tian H, Jheon AH, Klein OD. Ras signaling regulates stem cells and amelogenesis in the mouse incisor. J Dent Res. 2017 Nov;96(12):1438-44. Click Here to View
  16. Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD. Isl1 controls patterning and mineralization of enamel in the continuously renewing mouse incisor. J Bone Miner Res. 2017 Nov;32(11):2219-31. Click Here to View
  17. Klein OD, Duverger O, Shaw W, Lacruz RS, Joester D, Moradian-Oldak J, Pugach MK, Wright JT, Millar SE, Kulkarni AB, Bartlett JD, Diekwisch TG, DenBesten P, Simmer JP. Meeting report: a hard look at the state of enamel research. Intl J Oral Sci. 2017 Nov 22;9(11):e3. Click Here to View


  1. Tapaltsyan V, Charles C, Hu J, Mindell D, Ahituv N, Wilson GM, Black BL, Viriot L, Klein OD. Identification of novel Fgf enhancers and their role in dental evolution. Evol Dev. 2016 Jan;18(1):31-40. Click Here to View
  2. Jheon AH, Prochazkova M, Meng B, Wen T, Lim YJ, Naveau A, Espinoza R, Cox TC, Sone ED, Ganss B, Siebel CW, Klein OD. Inhibition of notch signaling during mouse incisor renewal leads to enamel defects. J Bone Miner Res. 2016 Jan;31(1):152-62. Click Here to View
  3. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. Human iPS cell-derived neurons uncover the impact of increased Ras signaling in Costello syndrome. J Neurosci. 2016 Jan;36(1):142-52. Click Here to View
  4. Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A. Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Mol Psychiatry. 2016 Oct;21(10):1417-33.  Click Here to View
  5. Du W, Prochazka J, Prochazkova M, Klein OD. Expression of FGFs during mouse tongue development. Gene Expr Patterns. 2016 Mar;20(2):81-7. Click Here to View
  6. Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD. Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone. 2016 Jul;88:170-9. Click Here to View
  7. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, Van Bakel H, Visel A, Williams TJ, Wysocka J; FaceBase Consortium, Chai Y. The FaceBase Consortium: A comprehensive resource for craniofacial researchers. Development. 2016 Jul;143(14):2677-88. Click Here to View
  8. Neben CL, Roberts RR, Dipple KM, Merrill AE, Klein OD. Modeling craniofacial and skeletal congenital birth defects to advance therapies. Hum Mol Genet. 2016 Oct;25(R2):R86-R93.  Click Here to View
  9. Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD. Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. JCI Insight. 2016 July;1(10). pii: e85395. Click Here to View
  10. Li C, Hu J, Lu H, Lan J, Du W, Galicia N, Klein OD. αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development. Nat Commun. 2016 Jul;7:12133. Click Here to View
  11. Shaffer JR, Orlova E, Lee MK, Leslie EJ, Raffensperger ZD, Heike CL, Cunningham ML, Hecht JT, Kau CH, Nidey NL, Moreno LM, Wehby GL, Murray JC, Laurie CA, Laurie CC, Cole J, Ferrara T, Santorico S, Klein O, Mio W, Feingold E, Hallgrimsson B, Spritz RA, Marazita ML, Weinberg SM. Genowide-wide association study reveals loci influencing normal human facial morphology. PLoS Genetics. 2016 Aug;12(8):e1006149. Click Here to View
  12. Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA. Genome-wide association study of facial variation in African children identifies association of SCHIP1 and PDE8A with facial size. PLoS Genetics. 2016 Aug;12(8):e1006174. Click Here to View
  13. Sharir A, Klein OD. Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol. 2016 Sep;214(6):645-7.Click Here to View
  14. Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci U S A. 2016 Sep;113(39):E5731-40. Click Here to View
  15. Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 Nov 15;143(22):4115-26. Click Here to View




  1. Barlow LA, Klein OD. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015 Jan;111:401-19. Click Here to View
  2. Jheon AH, Prochazkova M, Sherman M, Manoli DS, Shah NM, Carbone L, Klein OD. Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster). Int J Oral Sci. 2015 Mar;7(1):23-6. Click Here to View
  3. Dye BR, Hill DR, Ferguson MA, Tsai YH, Nagy MS, Dyal R, Wells JM, Mayhew CN, Nattiv R, Klein OD, White ES, Deutsch GH, Spence JR. In vitro generation of human pluripotent stem cell derived lung organoids. Elife. 2015 Mar;24:4.Click Here to View
  4. Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD. Opposing activities of notch and wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 2015 Apr;11(1):33-42. Click Here to View
  5. Thys A, Vandenberghe P, Hague P, Klein OD, Erneux C, Vanderwinden JM. Hyperplasia of interstitial cells of Cajal in Sprouty homolog 4 deficient mice. PLoS One. 2015 Apr;10(4):e0124861. doi: 10.1371/journal.pone.0124861. Click Here to View
  6. Tapaltsyan V, Eronen JT, Lawing AM, Sharir A, Janis C, Jernvall J, Klein OD. Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years. Cell Rep. 2015 May;11(5):673-80.  Click Here to View  [Cell Reports Cover - Click Here to View]
  7. Zarate YA, Perry H, Ben-Omran T, Sellars EA, Stein Q, Almureikhi M,Simmons K, Klein O, Fish J, Feingold M, Douglas J, Kruer MC, Si Y, Mao R, McKnight D, Gibellini F, Retterer K, Slavotinek A. Further supporting evidence for the SATB2-associated syndrome found through whole exome sequencing. Am J Med Genet A. 2015 May;167A(5):1026-32. Click Here to View
  8. Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. Transcriptome-wide analysis reveals hallmarks of human intestine development and maturation in vitro and in vivo. Stem Cell Reports. 2015 Jun;4(6):1140-55. Click Here to View
  9. Marangoni P, Charles C, Tafforeau P, Laugel-Haushalter V, Joo A, Bloch-Zupan A, Klein OD, Viriot L. Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model. Sci Rep. 2015 Jun;5:11658. doi: 10.1038/srep11658. Click Here to View
  10. Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet. 2015 Aug;24(15):4340-52. Click Here to View
  11. Goodwin AF, Kim R, Bush JO, Klein OD. From bench to bedside and back: improving diagnosis and treatment of craniofacial malformations utilizing animal models. Curr Top Dev Biol. 2015 Oct;115:459-92. Click Here to View
  12. Klein OD, Nör JE. Craniofacial stem cells in health and disease. J Dent Res. 2015 Nov;94(11)1485-6. Click Here to View
  13. Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein JL, Wittmann T, Klein OD. Migration of founder epithelial cells drives proper molar tooth positioning and morphogenesis. Dev Cell. 2015 Dec;35(6):713-24. Click Here to View


  1. Li C, Prochazka J, Goodwin A, Klein OD. Fibroblast growth factor signaling in mammalian tooth development. Odontology. 2014 Jan;102(1):1-13. Click Here to View
  2. Goodwin A, Tidyman W, Jheon A, Sharir A, Zheng X, Charles C, Fagin J, McMahon M, Diekwisch T, Ganss B, Rauen K, Klein OD. Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 2014 Feb;23(3):682-92. Click Here to View
  3. Kuang-Hsien Hu J, Mushegyan V, Klein OD. On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells. Genesis. 2014 Feb;52(2):79-92. Click Here to View
  4. Ching S, Cunha G, Baskin L, Basson M, Klein OD. Coordinated activity of Spry1 and Spry2 is required fornormal development of the external genitalia. Dev Biol. 2014 Feb;386(1):1-11. Click Here to View
  5. Zhao H, Feng J, Seidel K, Shi S, Klein OD, Sharpe P, Chai Y. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb;14(2):160-73. Click Here to View
  6. Mendelsohn BA, Jeng LL, Oberoi S, Klein OD. Dental findings in 14q terminal deletion syndrome. Clin Dysmorphol. 2014 Apr;23(2):60-2. Click Here to View
  7. Chavez MG, Hu J, Seidel K, Li C, Jheon A, Naveau A, Horst O, Klein OD. Isolation and culture of dental epithelial stem cells from the adult mouse incisor. J Vis Exp. 2014 May;(87). Click Here to View
  8. Yamada Y, Nakamura S, Klein OD, Ito K. Current trends in stem cell therapy for improvement of bone quality. Histol Histopathol. 2014 Jun;29(6):691-7.
  9. Goodwin AF, Oberoi S, Landan M, Charles C, Massie JC, Fairley C, Rauen KA, Klein OD. Craniofacial and dental development in Costello syndrome. Am J Med Genet A. 2014 Jun;164A(6):1425-30. Click Here to View
  10. Sun F, Wan M, Xu X, Gao B, Zhou Y, Sun J, Cheng L, Klein OD, Zhou X, Zheng L. Crosstalk between miR-34a and notch signaling promotes differentiation in Apical Papilla Stem Cells (SCAPs). J Dent Res. 2014 Jun;93(6):589-95. Click Here to View
  11. Naveau A, Seidel K, Klein OD. Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages. Exp Cell Res. 2014 Jul;325(2):96-103. Click Here to View
  12. Michailovici I, Harrington HA, Azogui HH, Yahalom-Ronen Y, Plotnikov A, Ching S, Stumpf MP, Klein OD, Seger R, Tzahor E. Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Development. 2014 Jul;141(13):2611-20. Click Here to View    [Commentary on our paper in Science Signalling - Click Here to View]
  13. Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug;141:2993-3002. Click Here to View
  14. Harjunmaa E, Seidel K, Häkkinen T, Renvoisé E, Corfe IJ, Kallonen A, Zhang ZQ, Evans AR, Mikkola ML, Salazar-Ciudad I, Klein OD, Jernvall J. Replaying evolutionary transitions from the dental fossil record. Nature. 2014 Aug;512(7512):44-8. Click Here to View   [Commentary on our paper in Nature - Click Here to View]
  15. Goodwin AF, Larson JR, Jones KB, Liberton DK, Landan M, Wang Z, Boekelheide A, Langham M, Mushegyan V, Oberoi S, Brao R, Wen T, Johnson R, Huttner K, Grange DK, Spritz RA, Hallgrímsson B, Jheon AH, Klein OD. Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia. Mol Genet Genomic Med. 2014 Sep;2(5):422-9. Click Here to View
  16. Mues G, Bond J, Xiang L, Vieira AR, Seymen F, Klein O, D'Souza RN. The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. Am J Med Genet A. 2014 Oct;164A(10):2455-60. Click Here to View



  1. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep 2013. Jan;3(1):70-8. Click Here to View
  2. Chavez MG,Yu W, Biehs B, Harada H, Snead ML, Lee JS, Desai TA, Klein OD. Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms. Tissue Eng Part C Methods. 2013 Jan;19(1):15-24. Click Here to View
  3. Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ. Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb;374(1):185-97. Click Here to View
  4. Yamada Y, Nakamura S, Ito K, Umemura E, Hara K, Nagasaka T, Abe A, Baba S, Furuichi Y, Izumi Y, Klein OD, Wakabayashi T. Injectable bone tissue engineering using expanded mesenchymal stem cells. Stem Cells. 2013 Mar;31(3):572-80. Click Here to View  [Cover of Stem Cells - Click Here to View]
  5. Jheon AH, Seidel K, Biehs B, Klein OD. From molecules to mastication: the development and evolution of teeth. Wiley Interdiscip Rev Dev Biol. 2013 Mar-Apr;2(2):165-82. Click Here to View
  6. Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I. Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development. 2013 Apr;140(7):1424-32. Click Here to View
  7. Nusse YM, Klein OD. If a stem cell dies in the crypt, and no one is around to see it.. Cell Stem Cell. 2013 Apr;12(4):389-90. Click Here to View
  8. Goodwin AF, Oberoi S, Landan M, Charles C, Groth J, Martinez A, Fairley C, Weiss LA, Tidyman WE, Klein OD, Rauen KA. Craniofacial and dental development in cardio-facio-cutaneous syndrome: the importance of Ras signaling homeostasis. Clin Genet. 2013 Jun;83(6):539-44. Click Here to View
  9. Felfly H, Klein OD. Sprouty genes regulate proliferation and survival of human embryonic stem cells. Sci Rep. 2013 Jul;3:2277.doi: 10.1038/srep02277. Click Here to View
  10. Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013 Jul;15(7):846-52. Click Here to View
  11. Lagronova-Churava S, Spoutil F, Vojtechova S, Lesot H, Peterka M, Klein OD, Peterkova R. The dynamics of supernumerary tooth development are differentially regulated by sprouty genes. J Exp Zool B Mol Dev Evol. 2013 Jul;320(5):307-20. Click Here to View
  12. Jones KB, Goodwin AF, Landan M, Seidel K, Tran DK, Hogue J, Chavez M, Fete M, Yu W, Hussein T, Johnson R, Huttner K, Jheon AH, Klein OD. Characterization of X-linked hypohidrotic ectodermal dysplasia (XL-HED) hair and sweat gland phenotypes using phototrichogram analysis and live confocal imaging. Am J Med Genet A. 2013 Jul;161A(7):1585-93. Click Here to View
  13. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus M, Klein OD, Amendt BA. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013 Aug;140(16):3348-59. Click Here to View
  14. Jones KB, Klein OD. Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey. Int J Oral Sci. 2013 Sep;5(3):121-9. Click Here to View
  15. Oishi PE, Klein OD, Keller RL; University of California San Francisco Neonatology and Pediatric Critical Care Early Faculty Development Committee. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy. J Pediatr. 2013 Sep;163(3):616-7. Click Here to View
  16. Zheng L, Warotayanont R, Stahl J, Kunimatsu R, Klein OD, Denbesten PK, Zhang Y. Inductive ability of human developing and differentiated dental mesenchyme. Cells Tissues Organs. 2013 Oct;198(2):99-110. Click Here to View
  17. Klein OD, Oberoi S, Huysseune A, Hovorakova M, Peterka M, Peterkova R. Developmental disorders of the dentition: An update. Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):318-32. Click Here to View
  18. Klein OD, Bush JO, Knox SM, Jheon AH, Cordero DR, Richtsmeier JT. The society of craniofacial genetics and developmental biology 35th annual meeting. American Journal of Medical Genetics Part A. 2013 Dec;161(12):2938-52. Click Here to View



  1. Collaborative cross consortium. The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics. 2012 Feb;190(2):389-401. Click Here to View   [Cover of Genetics - Click Here to View]
  2. Purcell P, Jheon A, Vivero MP, Rahimi H, Joo A, Klein OD. Spry1 and spry2 are essential for development of the temporomandibular joint. J Dent Res. 2012 Apr;91(4):387-93. Click Here to View
  3. Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M. BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012 May;7(5):e37670. doi: 10.1371/journal.pone.0037670. Click Here to View
  4. Li CY, Cha W, Luder HU, Charles RP, McMahon M, Mitsiadis TA, Klein OD. E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor. Dev Biol. 2012 Jun;366(2):357-66. Click Here to View
  5. Horst OV, Chavez MG, Jheon AH, Desai T, Klein OD. Stem cell and biomaterials research in dental tissue engineering and regeneration. Dent Clin North Am. 2012 Jul;56(3):495-520. Click Here to View
  6. Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, Klein OD, Thesleff I, Michon F. Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell. 2012 Aug;23(2):317–28. Click Here to View
  7. Wan M, Gao B, Sun F, Tang Y, Ye L, Fan Y, Klein OD, Zhou X, Zheng L. microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells. PLoS One. 2012 Nov;7(11): e50090. doi: 10.1371/journal.pone.0050090.  Click Here to View
  8. Justice C, Yagnik G, Kim Y, Peter Y, Jabs W, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeierc JT, Heuzé Y, Sanchez-Lara P, Buckley MF, Drusche CF, Mills J, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA. A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9. Nature Genetics. 2012 Dec;44(12):1360-4. Click Here to View



  1. Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Chénier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer AM, Megarbane A, Mendelsohn NJ, Meschino WS, Mortier GR, Parkash S, Ray CR, Roberts A, Roberts A, Reardon W, Schnur RE, Smith R, Splitt M, Tezcan K, Whiteford ML, Wong DA, Zori R, Lin AE. Genotype-phenotype analysis of the branchio-oculo-facial syndrome. Am J Med Genet A. 2011 Jan;155A(1):22-32. Click Here to View
  2. Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD. PERP regulates enamel formation via effects on cell–cell adhesion and gene expression. J Cell Sci. 2011 Mar;124(Pt5):745-54. Click Here to View
  3. Petersen CI, Jheon AH, Mostowfi P, Charles C, Ching S, Thirumangalathu S, Barlow LA, Klein OD. FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genetics. 2011 Jun;7(6):e1002098. doi: 10.1371/journal.pgen.1002098. Click Here to View
  4. Hovorakova M, Prochazka J, Lesot H, Smrckova L, Churava S, Boran T, Kozmik Z, Klein O, Peterkova R, Peterka M. Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor. J Exp Zoolog B Mol Dev Evol. 2011 Jul;316(5):347-58. Click Here to View
  5. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul;355(2):175-82. Click Here to View
  6. Charles C, Hovorakova M, Ahn Y, Lyons DB, Marangoni P, Churava S, Biehs B, Jheon A, Lesot H, Balooch G, Krumlauf R, Viriot L, Peterkova R, Klein OD. Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling. Development. 2011 Sep;138(18):4063-73. Click Here to View
  7. Jheon AH, Li CY, Wen T, Michon F, Klein OD. Expression of microRNAs in the stem cell niche of the adult mouse incisor. PLoS One. 2011 Sep;6(9):e24536. doi: 10.1371/journal.pone.0024536. Click Here to View
  8. Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature. 2011 Sep;478(7368):255-9. Click Here to View   [Commentary on our paper in Nature Reviews - Click Here to View]



  1. Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K. Dact1-3 mRNAs exhibit distinct expression domains during tooth development. Gene Expr Patterns. 2010;10:140-3. Click Here to View
  2. Prochazka J, Pantalacci S, Rothova M, Churava S, Lambert A, Lesot H, Klein O, Peterka M, Laudet V, Peterkova R. Patterning by heritage: rudimentary tooth buds shape mouse molar row development. Proc Natl Acad Sci U S A. 2010;107:15497-502. Click Here to View
  3. Jelin A, Perry H, Hogue J, Oberoi S, Cotter PD, Klein OD. Clefting in trisomy 9p patients: genotype-phenotype correlation using microarray comparative genomic hybridization. J Craniofac Surg. 2010 Sep;21(5):1376-1379. Click Here to View
  4. Ahn Y, Sanderson BW, Klein OD, Krumlauf R. Inhibition of Wnt signaling by Wise/Sostdc1 and negative feedback from Shh controls tooth number and patterning. Development. 2010 Oct;137(19):3221-31. Click Here to View
  5. Parsa S, Kuremoto K, Seidel K, Tabatabai R, MacKenzie B, Yamaza T, Akiyama K, Branch J, Koh CJ, Al Alam D, Klein OD, Bellusci S. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010 Nov;137(22):3743-52. Click Here to View
  6. Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RAD, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development. 2010 Nov;137(22):3753-61. Click Here to View



  1. Caton J, Luder H-U, Zoupa M, Bradman M, Bluteau G, Tucker AS, Klein O, Mitsiadis TA. Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors. Dev Biol. 2009 Apr;328(2):493-505. Click Here to View
  2. Peterkova R, Churava S, Lesot H, Rothova M, Prochazka J, Peterka M, Klein OD. Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis. J Exp Zoolog B Mol Dev Evol. 2009 Jun;312B(4):292-308. Click Here to View
  3. Boran T, Peterkova R, Lesot H, Lyons DB, Peterka M, Klein OD. Temporal analysis of ectopic enamel production in incisors from Sprouty mutant mice. J Exp Zoolog B Mol Dev Evol. 2009 Jul;312B(5):473-85. Click Here to View
  4. Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot, L. Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition. Proc Natl Acad Sci U S A. 2009 Dec;106(52):22364-8. Click Here to View   [Commentary on our paper in Nature - Click Here to View]



  1. Klein OD, Lyons DB, Balooch G, Marshall GW, Basson MA, Peterka M, Boran T, Peterkova R, Martin GR. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development. 2008 Jan;135(2):377-85. Click Here to View   [Summary of our paper in Development - Click Here to View]
  2. Metzger RJ, Klein OD, Martin GR, Krasnow MA. The branching programme of mouse lung development. Nature. 2008 Jun;453(7196):745-50. Click Here to View   [Commentary on our paper in Nature - Click Here to View]
  3. Klein OD, Kostiner DR, Weisiger K, Moffatt E, Lindeman N, Goodman S, Tuchman M, Packman S. Acute fatal presentation of ornithine transcarbamylase deficiency in a previously healthy male. Hepatol Int. 2008 Sep;2(3):390–4. Click Here to View
  4. Kalfa N, Liu B, Klein O, Audran F, Wang MH, Cao M, Sultan C, Baskin L. Mutations of cxorf6 are associated with a range of severities of hypospadias. Eur J Endocrinol. 2008 Oct;159(4):453-8. Click Here to View
  5. Kalfa N, Liu B, Klein O, Wang MH, Cao M, Baskin L. Genomic variants of atf3 in patients with hypospadias. J Urol. 2008 Nov;180(5):2183-8. Click Here to View



  1. Klein OD, Cotter PD, Moore MW, Zanko A, Gilats M, Epstein CJ, Conte F, Rauen KA. Interstitial deletions of chromosome 6q: genotype-phenotype correlation utilizing array CGH. Clin Genet 2007 Mar;71(3):260–6. Click Here to View
  2. D'Souza RD and Klein OD. Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches. Cells, Tissues, Organs 2007 Jul;186(1):60–9 Click Here to View



  1. Klein OD, Minowada G, Peterkova R, Kangas A, Yu BD, Lesot H, Peterka M, Jernvall J, Martin GR. Sprouty genes control tooth number via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell. 2006 Aug;11(2):181-90. Click Here to View
  2. Enns G, Cowan T, Klein O, Packman S. Aminoacidopathies and organic acidemias. In: Swaiman K, Ashwal S, Ferriero D, eds. Pediatric Neurology: Principles and Practice. Philadelphia: Elsevier, 2006.


2005 and earlier

  1. Klein OD, Backstrand K, Cotter PD, Marco E, Sherr E, Slavotinek A. Case report: Y;6 translocation with deletion of 6p. Clin Dysmorphol. 2005 Apr;14(2):93-6. Click Here to View
  2. Ahn CP, Lachman RS, Cox VA, Blumberg B, Klein OD. Brachydactylic multiple delta phalanges plus syndrome. Am J Med Genet A. 2005 Sep;138(1):41-4. Click Here to View
  3. Klein OD, Cotter PD, Schmidt AM, Bick DP, Tidyman WE, Albertson DG, Pinkel D, Rauen KA. Interstitial deletion of chromosome 12q: Genotype-phenotype correlation of two patients utilizing array comparative genomic hybridization. Am J Med Genet A. 2005 Nov;138(4):349-54. Click Here to View
  4. Klein OD, Cotter PD, Albertson DG, Pinkel D, Tidyman WE, Moore MW, Rauen KA. Prader-Willi syndrome resulting from an unbalanced translocation: characterization by array comparative genomic hybridization. Clin Genet. 2004 Jun;65(6):477-82. Click Here to View
  5. Klein O, Kegler-Ebo D, Su J, Smith S, DiMaio D. The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells. J Virol. 1999 Apr;73(4):3264-72 Click Here to View
  6. Raga F, Bonilla-Musoles F, Casañ EM, Klein O, Bonilla F. Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity. Hum Reprod. 1999 Nov;14(11):2851-4.Click Here to View
  7. DiMaio D, Lai CC, Klein O. Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways. Annu Rev Microbiol. 1998 Oct; 52:397-421. Click Here to View
  8. Klein O, Polack GW, Surti T, Kegler-Ebo D, Smith SO, DiMaio D. Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation. J Virol. 1998 Nov;72(11):8921-32. Click Here to View
  9. Surti T, Klein O, Aschheim K, DiMaio D, Smith SO. Structural models of the bovine papillomavirus E5 protein. Proteins. 1998 Dec;33(4):601-12. Click Here to View
  10. Lee ME, Dyer DH, Klein OD, Bolduc JM, Stoddard BL, Koshland DE, Jr. Mutational analysis of the catalytic residues lysine 230 and tyrosine 160 in the NADP(+)-dependent isocitrate dehydrogenase from Escherichia coli. Biochemistry. 1995 Jan;34(1):378-84. Click Here to View